In Houben-Weyl, transformations of the principal functional group are illustrated by typical examples. Patents are included in the scope of coverage, and the important preparative methods for all classes of compounds are presented. The Houben-Weyl legacy archive has been available online since and is included as the backfile in the electronic version of Science of Synthesis. Science of Synthesis is an entirely new edition of Houben-Weyl designed to cater to the broader information needs of the synthetic organic chemist today.
It is considered to be the best secondary source of information other than the original journal articles for methods of synthesis of the functional groups covered. It consists of 48 volumes to be published in print and online between and As of mid, 28 of the volumes had been published, with the majority available online. Over renowned organic chemists worldwide have been involved with or are currently working on contributions to the project. The purpose of Science of Synthesis is to critically evaluate all existing methods in organic and organometallic chemistry.
The most important molecular transformations for a product class are selected and their scope and limitations summarized. In addition the transformations are further illustrated using proven general or typical methods. Contributions contain background information, a comparison of methods, mechanistic rationale, stereochemistry, experimental procedures, information on scope, limitations and problems, functional group compatibility, and safety and environmental aspects. The organization of Science of Synthesis is based on the structural unit or functional group for example, a heteroaromatic ring or an enone that is to be constructed.
That is to say, the classification is based on the product how do I make something? Thus, a synthetic method, such as catalytic hydrogenation, that can be employed for a variety of product types, will be found throughout the work, depending on the structure of the compound produced. Likewise, the various reactions of a given compound class, such as alcohols, are located throughout the work on the basis of the product.
The online product has been available since and supports combined keyword, text, and reaction searches. Version 3. Crossovers to databases and electronic journals are fully supported, thus allowing chemists to gather further information about their target compounds. The electronic product has browsing features and an interactive table of contents to enable easy navigation within the product. The product is better described as an e-reference book as opposed to a database because of the wealth of knowledge around each of the reactions and the context within which they are presented.
Science of Synthesis Start Page. Science of Synthesis Benzofuryllithium Page. Organic Syntheses began publication in and is published annually.
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The procedures are cumulated into collective volumes with revisions if necessary. Ten of the collective volumes covering annual volumes have been published to date. The articles are sufficiently detailed so that the reactions described can usually be carried out without consulting the original primary literature.
In later years, the emphasis has been on model compounds and procedures that illustrate important types of reactions. The Organic Syntheses Reaction Guide covers experimental procedures in Collective Volumes and annual volumes Eleven broad classes of reactions are used to index the reactions. It requires the installation of the free ChemDraw Net plugin from CambridgeSoft, but once that is in place, even structure searches can be performed.
Additional ways of searching the database include CAS RN, molecular formula, and chemical name, plus author and keyword searching. Below is the result of a structure search on Organic Syntheses for Isatin. As is typical of the long publication span of most treatises, Inorganic Reactions and Methods began publication in and was completed in Volumes cover ways of forming bonds with inorganic elements, methods of effecting various types of reactions, and methods of characterizing the compounds.
The set is well indexed. Of particular note is a permuted formula index which groups all compounds containing a given number of an element in one section of the index. A longstanding inorganic series that has appeared since is Inorganic Syntheses , for which a collective index of volumes of the series covering , has now appeared. The Encyclopedia of Inorganic Chemistry in 8 volumes covers all aspects of inorganic chemistry, including information on reactions and bonding energetics.
Pergamon Press has published a large number of multi-volume treatises on various areas of chemistry over the years:. A major thrust of the Pergamon treatises is syntheses and reactions. Each of the sets has a distinguished editorial board and is thoroughly referenced to the original primary literature. A feature of some of the treatises is an index of review articles and specialist textbooks relevant to the topic.
It is often useful to find a description of a reagent to determine whether it has been used in the preparation of a given compound or a compound that is similar to the one which is to be made. A recent set is the 8-volume Encyclopedia of Reagents for Organic Synthesis The preface to the work notes the "vital need to know which reagent will perform a specific transformation.
These include reagents, auxiliaries, and catalysts for C-C bond formation; oxidizing and reducing agents; acidic and basic reagents; activating agents and protecting groups; chiral reagents for asymmetric synthesis; reagents for high-throughput solid-phase and solution-phase organic synthesis; reagents for glycoside, nucleotide, and peptide synthesis; and reagents for direct functionalization of C-H bonds. The set is indexed by formula, structural class, function, and subject indexes.
Intended as a lower-cost reference work that would be available in or near laboratories, the Handbook includes information from the original 8-volume work. It is especially useful for planning a synthesis and for answering questions that may arise in the course of a synthesis. One can find information on methods of preparation or purification, uses, suppliers, and reaction diagrams.
Indexes for reactions, methods, authors, and subjects are provided. Larock's Comprehensive Organic Transformations: A Guide to Functional Group Preparations first appeared in , with coverage of the literature through A CD-ROM version of the first edition of the work appeared in , and the revised print edition, published in , extended the literature coverage for selected journals through More thorough coverage of "The Chemistry of Functional Groups" can be found in the volumes that bear that series name.
Bretherick's Reactive Chemical Hazards is the place to look for information on all types of dangerous reactions.
Included is every chemical for which documented information on reactive hazards has been found over the years. However, there are a number of special services that are devoted to reaction or synthetic chemistry. EPA Alumni Association. Retrieved 1 January Audsley, G. The Art of Organ Building. Baird, C.
Environmental Chemistry 5th ed. Freeman and Company. Becker, M. Inorganic Chemistry. Beeman, J. European Physical Journal A. Bibcode : EPJA Beiner, G. Collection Forum. Bharara, M. Lead: Inorganic Chemistry.
Bisel, S. In Jashemski, W. The Natural History of Pompeii. Cambridge University Press. Bisson, M. Blakemore, J. Solid State Physics.
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Bouchard, M. Archives of General Psychiatry. Bremner, H. Safety and Quality Issues in Fish Processing. Brenner, G. Brescia, F. Fundamentals of Chemistry: A Modern Introduction. Bretherick, L. Bretherick's Handbook of Reactive Chemical Hazards. Bunker, B.
The Aqueous Chemistry of Oxides. Oxford University Press. Burbidge, E. Reviews of Modern Physics.
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Bibcode : RvMP Burleson, M. California Department of Fish and Wildlife.
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- CRC Handbook of Enthalpy Data of Polymer-Solvent Systems.
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- Recovery of tin and copper by recycling of printed circuit boards from obsolete computers.
Retrieved 17 May Journal of Roman Archaeology. Cama, T. The Hill. Retrieved 30 May Cangelosi, V. In Roduner, E. Royal Society of Chemistry.
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