Cancer Inhibitors from Chinese Natural Medicines


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My Wishlist Sign In Join. Be the first to write a review. Add to Wishlist. Ships in 7 to 10 business days. Link Either by signing into your account or linking your membership details before your order is placed. Description Table of Contents Product Details Click on the cover image above to read some pages of this book! Anticancer activities of exogenous pathogenic factor-eliminating herbs. Anticancer activities of antipyretic herbs.

Anticancer activities of anti-rheumatics herbs. Anticancer activities of internal cold-dispelling herbs. Anticancer activities of vital energy-regulating herbs. Anticancer activities of blood-activating and stasis-resolving herbs. Anticancer activities of hemostatic herbs. Anticancer activities of expectorant, antitussive and anti-asthmatic herbs. Anticancer activities of tonic herbs. JWXYS are used for invigorating the spleen and nourishing blood, it is effective for relieving Qi stagnancy in liver. Both of these formulae have been safely used in liver cancer treatment for patients in China, Taiwan and Hong Kong, with few side effects being reported.

Some pharmacological studies also revealed that a lot of CMs extracts or isolates could inhibit liver cancer growth or metastasis both in vitro and in vivo. This includes but not limited to Coptidis Rhizome extracts, Radix Bupleuri extracts, Radix Salvia Miltiorrhiza extracts, silymarin, berberine, Wogonin, bufalin and curcumin [ 25 — 28 ]. In this case, improving the quality of life and reducing the side effects of conventional therapy are very important for liver cancer patients.

INTRODUCTION

According to a series of randomized clinical trials, CMs are effective in extending survival time, improving quality of life, and reducing side effects of conventional therapies for liver cancer patients [ 29 ]. In vivo studies also confirmed that JDXZY could increase the tumor apoptotic index and reduce tumor size in nude mice. Previous studies found that bufalin exhibited significant anticancer activities in many cancer cell lines in vitro and in vivo.

Modern science has demonstrated that one of the major active components in Gekko swinhonis Guenther is sulfated polysaccharide—protein complex GSPP. Many researches have revealed the strong anticancer activity of berberine. The protective effects of berberine on liver diseases including liver cancer have been widely studied by our groups.

Panax Notoginseng is a famous hemostatic in TCM and it can also relieve other blood disorders, such as blood stasis or blood deficiency. Ultrastructure morphology observation confirmed that there have obvious cell morphologic changes after panaxydol treatment. The activity of several differentiation related proteins such as alkaline phosphatase and albumin were increased, while AFP activity was significantly decreased after panaxydol treatment.

These results showed that panaxydol may be a potential antihepatoma agent by inducing tumor cell differentiation. Gepsin can also inhibit liver cancer development by inducing cancer cells differentiation. Ginseng is one of the most widely used herbs in TCM for thousands of years. There are many reports verified the anticancer effect of ginsenosides in vitro and in vivo. Recent studies have revealed its anticancer effects through inhibition invasion and metastasis of HCC cells [ 38 ].

The Traditional Chinese Medicine Diet

GSPP treatment remarkably decreased the concentration of intracellular calcium. Many studies have demonstrated that low intracellular calcium concentration is associated with reduced cancer migration. GSPP treatment could remarkably decrease the concentration of intracellular calcium.

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Thus, the antimigration effect by GSPP may be partially a consequence of downregulation of intracellular calcium concentration together with an upregulation of actin filaments polymerization in HCC cells. Recent studies also found that aqueous extracts of Radix Salviae can inhibit the development of liver cancer by suppressing the metastasis and recurrence in animal models [ 21 ].

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Cancer Inhibitors from Chinese Natural Medicines | Taylor & Francis Group

The tumor xenograft mice model also confirmed the antimetastasis effects of Radix Salviae on posthepatectomy liver cancer in vivo. However, due to its poor aqueous solubility, the clinical application of curcumin has been limited. A recent study has used the polymeric nanoparticle formulation of curcumin to improve its solubility as well as anticancer activity [ 39 ].

The results showed that when used as a combination with sorafenib, the modified curcumin can suppress the proliferation and invasion of HCC cells in vitro. Furthermore, in vivo study also found curcumin could inhibit liver cancer growth and lung metastases. Taken together, the polymeric nanoparticle formulation of curcumin may exhibit antitumor activity by inhibiting liver cancer metastasis. Angiogenesis is a physiological process during which new blood vessels are produced and developed based on the original vessels.

As angiogenesis plays a crucial role in tumor growth and metastasis, the novel antitumor therapies targeting angiogenesis may provide new hopes for cancer treatment. Some clinical trials indicated that YZXJ may improve the curative effect of interventional chemotherapy for advanced liver cancer patients.

Asparagus polysaccharide, the bioactive derivate from Asparagus, is a common TCM herbal diet that may exhibit anticancer activity according to previous researches. One study has explored the adjunctive effects of asparagus polysaccharide in liver cancer chemotherapy [ 42 ].


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Their results showed that asparagus polysaccharide significantly suppressed liver cancer growth in combination with transcatheter arterial chemoembolization TACE therapy in orthotopic HCC rat model. Tumor angiogenesis may be the major target for asparagine gelatinous in liver cancer treatment. The expression of MVD markers also remarkably reduced in asparagus polysaccharide treated liver tumors. These results suggested that asparagus polysaccharide with TACE could apparently inhibit the tumor angiogenesis in vivo ; asparagus polysaccharide might be a potential adjunvant therapy for TACE in treating liver cancer.

Recent studies found that Mylabris mixture could obviously suppress the growth of liver cancer H22 cells by improving the immunological function in mice model [ 44 ].


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The subpopulation percentage of T lymphocytes also significantly increased after Mylabris mixture treatment. The electron microscope results observed that the microvilli on the surface of the lymphocytes attacked the cancer cells. The membrane of tumor cell in contact with the sensitized T lymphocyte became broken with the organelle and the nucleus dissolved and the vacuolation of the cytoplasm as well.

According to a clinical study, KLT treatment can improve the immunological function via increasing the proportion of T cells and NK cells in the blood of HCC patients [ 46 ]. Astragaloside has been reported to be an effective agent in reversing multidrug resistance MDR of cancer treatment.

Thus, astragaloside may be a potential anticancer drug for reversing drug resistance in liver cancer treatment. Villatoro, B. Chrysophanic acid, chrysophanein and chaparrin from. Phytochemistry , , 13 9 , Hagiwara, H. Catalytic performance of ruthenium-supported ionic-liquid catalysts in sustainable synthesis of macrocyclic lactones.

Acta , , 93 1 , Piao, H. Study on chemical constituents of petroleum ether fraction from caragana microphylla lam. Li Shizhen Med. Materia Medica Res. Jin, X. Studies on natural anthraquinone antitumor active ingredients and preparation of derivatives. Steroids , , 70 13 , Seebacher, W. MRC , , 41 8 , Jones, K. Modulation of melanogenesis by aloesin: A competitive inhibitor of tyrosinase.

Pigment Cell Res. Plumb, J. Cell sensitivity assays: The MTT assay. Methods Mol. Twentyman, P. A study of some variables in a tetrazolium dye MTT based assay for cell growth and chemosensitivity.

Anti-cancer natural products isolated from chinese medicinal herbs

Cancer , , 56 3 , Ni, H. Identification of adenosine deaminase inhibitors from Tofu wastewater and litchi peel and their synergistic anticancer and antibacterial activities with cordycepin. Food Sci. Chen, W. Cancer statistics in China, CA Cancer J. Hidaka, T. Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-beta-D-arabinofuranosyladenine. Wu, J. Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions.

Agents Chemother. Tuli, H. Cordycepin: A bioactive metabolite with therapeutic potential. Life Sci.

Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines Cancer Inhibitors from Chinese Natural Medicines
Cancer Inhibitors from Chinese Natural Medicines

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